The Hunter-Gatherer ([info]faustin) wrote,
@ 2009-05-30 11:31:00
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what, me update? The ugly wake-up
Trying to restart (blogging) with baby steps.

Most days are near perfect. Seriously, I mean that, despite the following which is the ugly part.


Almost everyday I wake up sick, in pain, and miserable, due to the following weird dynamic between my sleep cycles and my insulin schedule. My body preps itself to wake based on the wake times it has already adapted to. This prep process includes the big cortisol release, which amps up blood glucose.

My sleep cycle gets set mostly by my need to inject Levemir (long-acting insulin) at 06:00. So my body revs up at about 5:15-5:30, my surging blood sugar sickens me and wakes me up by 05:30. I take my blood sugar, and it's usually high, which pisses me off. CRITICAL: I don't think I fully understand what causes the inconsistent morning highs. It's about 67-75% of days that are like this.

Of course, if my surging blood sugar at ~5:20 keeps waking me up, what happens next? Naturally, my body adapts to the expected wake time of 5:30 (I've been laying there with my dreams disturbed by the feeling of sickness, coming conscious, slowly realizing that my BG is high and that's what's wrong.)

You would expect a continuing feedback loop, pushing me to earlier and earlier wake time / prep process / cortisol release. My morning schedules, I believe, short circuit that. Some days require big correction. Some corrections knock me out, and I roll with this, because I don't have a client until 08:00. Most days I have clients at 06:30, 07:00 or 07:30 so my actual Jump Up and Hit It Hard times vary.

The inconsistency seems to confuse my body's adaptation. About 1/2 or 1/3 of the time, I wake up at 04:30 with my blood sugar amping up high ---- presumably in anticipation of the 5:30 wake up which was caused by antiicipation of the 06:00 wake up. Many days, this HIGH is 280-330, which is a crushing blow to my AVG BG and STANDARD DEVIATIONs, which lately are the most important numbers in my life.

The next 2 hours is made miserable by the timing and effect of corrective insulin and the pressures of my morning's activity. I take Novolog, my preferred fast-acting insulin, to correct my high blood sugar. Because of the "dawn phenomenon" (this whole body-prep process which amps up BG and also decreases insulin sensitivity), the insulin takes a long time to act.

I lay back down, feeling sick, and the Novolog makes me drowsy and finally knocks me out about 45 minutes later --- about 5-10 minutes before I have to jump up out of bed and get ready in < 20 minutes. This is extraordinarily difficult: to rouse oneself from a smothering insulin surge. I hate it.

The ordeal doesn't always end there. If I have a "date" to workout with someone, at perhaps 06:30 or 07:00 or 07:30, the insulin surge makes me extremely weak. Once in a while, I'll be unable to force myself through the workout. This has happened about 3 times in the past year. The mental effects are much clearer, as I'm slow and muddled. Sometimes, I have planned a client's workouts in advance but cannot remember what I planned, which can be very frustrating.

* * *
Want a happy ending? Most of this misery (not all of it) is caused by my insulin schedule of injecting Levemir. I do three daily injections of Levemir, which is unusual. The insulin is designed to be injected once every 24 hours. The marketing hype promises that you can inject it once and have a stable, even delivery, keeping your blood sugar level in the absence of meals (you take care of the meals by injecting a different, fast-acting insulin).

I found that Levemir does NOT offer a stable, even delivery over 24 hours. I had to switch to TWO injections a day. I still experienced a curve -- less delivery at the beginning, then heightened delivery, then waning delivery. If you get this big curve over a 24 hour period, you have very poor blood sugar control. If you break up the 24 hours into 2 curves, you get some overlapping effect, which mitigates the different deliveries. I have had to break it up into 3 overlapping curves. Hence my Levemir injection schedule, at 06:00, 14:00 and 22:00.

The happy ending: I'm restarting on the insulin pump very, very soon. Insurance is reviewing my claim / prescription data and will confirm in about two weeks. This is going to be a tremendous improvement to my life.



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[info]waitingforoct
2009-05-31 12:49 am UTC (link)
My recent clinical experience with Levemir is like yours. At the hospital we recently switched from carrying Lantus to Levemir. (Plenty of patients require twice daily injections of Lantus anyway, but not 3x/day). Anyway, we've definitely noticed a "peak phenomenon" with Levemir that we didn't see with Lantus, and is not supposed to happen. We are conducting our own review of all the patients on Levemir, but it definitely doesn't act as advertised. If you are injecting 3 times anyway, you should just switch back to N, which is more predicatable (or switch to Lantus twice a day).

http://www.dlife.com/dLife/do/ShowContent/inspiration_expert_advice/expert_columns/garnero_0106.html

Do you ever test at 0200? Are you sure you're not bottoming out in the middle of the night and are just having some rebound?

Anyway, isn't your wife an endocrinologist? She would be able to help you better than me.

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[info]faustin
2009-05-31 04:01 am UTC (link)
Huh, I never thought of switching back to NPH. For the record, NPH also has a curve, however.

I used Lantus for quite a while, and... to throw another curve in, Lantus causes depression for me. So Levemir is actually an improvement.

Do you ever test at 0200? Are you sure you're not bottoming out in the middle of the night and are just having some rebound?

Yes, I do. It took me about a year to convince my wife that I wasn't rebounding from lows. But in fact I'm not. Testing at 0200 was one of the things that helped convince her. Although it's pretty common for me to be awake at 0200 and 0300... more to the point, I've done basal testing in just about every conceivable figuration, 50 ways from Sunday. My sleep cycles have always been convoluted, as have my eating patterns, which can make it hard to isolate variables, and in some cases, make it easier or unnecessary.

Tash has been working with an endo lately. The endo is by-the-by learning a lot as a result. :-)

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[info]faustin
2009-06-12 05:09 pm UTC (link)
I feel like such a jerk missing that you were due for delivery, and I haven't been reading, so Tash just told me last night that you had delivered. Congratulations!!! I'm really happy for you and Dave. I want to come read your update ASAP and call you guys.

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[info]fitfool
2009-06-03 10:35 am UTC (link)
It surprises me whenever I remember that you have to work hard to get your body to keep your insulin levels steady.

Do you have any Walgreens near you? They're having a sale this week (through June 6) on Bayer Contour and Bayer Breeze 2 glucose meters. They're each $10 and then it prints out a RegisterReward coupon for $10 off your next purchase at Walgreens. (You have to buy them one at a time and if you use the $10 RR on your next meter, then the next $10RR won't print out.) The Bayer Contour comes with 10 test strips and the Breeze2 comes with a single 10-test disc.

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[info]laffingkat
2009-06-11 05:32 am UTC (link)
Glad to see you post again. I hope you get the morning BG sorted out!

I'm on Lantus twice a day and Novolog for meals right now. Sometimes it works, sometimes not so much. I can't find any lasting pattern, nor can any of the endocrinologists I've worked with. Plus I go on and off prednisone periodically, and that always throws me off. But I don't seem to have any complications yet other than a bit of retinopathy and a frozen shoulder, so I'm just hoping to stay functional until something better comes along.

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[info]faustin
2009-06-12 05:13 pm UTC (link)
It seems that greater variance in my injection sites is working wonders for me. I had these inexplicable variations and non-effectiveness of my insulin. Well, and the same old BRUTE FORCE method of giving tons of attention to my BG seems to be working for me lately.

The seeming loss of vision scared the bejeezus out of me, which has fueled a lot of my hyper-attentiveness lately.

Do you think the frozen shoulder is connected to BG control? I'm not familiar with that.

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[info]laffingkat
2009-06-14 11:57 pm UTC (link)
Oh, good to know that varying injection sites more has helped you!

I've learned over the years not to take vision problems too seriously. I have glasses to correct my astigmatism and have just gotten used to my vision changing with my blood sugar and other aspects of my health. It was pretty scary for a while since my work (editing) is totally dependent on my vision, but unless we've got a huge deadline, my work schedule is usually flexible, and any vision problems are generally quite temporary. And I have a terrific ophthalmologist who is very reassuring and tells me they are making significant advances all the time.

I think there is probably some relationship between BG control and frozen shoulder, but I have no idea how significant it is. The condition is much more common among diabetics than in the general population, as are a number of other joint problems. But it's also apparently more common among people with thyroid disease, and I don't recall having any joint problems before developing RA, so I'm not sure how much is directly related to BG control versus just being an autoimmune problem, or something else related to metabolic abnormalities (I never seem to be able to find information about whether the diabetes or thyroid disease in question is only the autoimmune varieties all or types). In my case, it may have been caused more by inactivity while I was crippled by the RA until we found treatments that worked, or triggered by an injury that wasn't diagnosed in time. No one seems to know what actually causes frozen shoulder, just various correlations. I've even read some articles suggesting that there is no cause, which really annoys me!

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